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Emerging DiagnosticMetabolic HealthUpload compatible
Methylation Panel
Decode the master biochemical process behind detox, mood, and DNA repair
$300–$50010–14 business days2 ordering options
What Gabriel reads for
Homocysteine (methylation bottleneck marker)
SAMe (S-adenosylmethionine — primary methyl donor)
SAH (S-adenosylhomocysteine)
Cost
$300–$500
Turnaround
10–14 business days
Ordering path
Doctor's Data
Results flow
Upload + interpret in Gabriel
What this test reveals
What this test reveals
Methylation panel testing measures key markers in the methylation cycle — homocysteine, SAMe, SAH, methylmalonic acid, and B-vitamin cofactors — revealing how efficiently your body is performing this critical biochemical process that affects detoxification, neurotransmitter production, DNA repair, and gene expression.
Methylation is arguably the most important biochemical process in your body. It's required for making neurotransmitters, detoxifying chemicals and hormones, repairing DNA, and controlling gene expression. When methylation is impaired, everything suffers.
People usually reach for this kind of diagnostic when they want a clearer read on homocysteine (methylation bottleneck marker), same (s-adenosylmethionine — primary methyl donor), sah (s-adenosylhomocysteine), especially when symptoms or prior testing still leave blind spots.
Once results are back, you can upload them into Gabriel to connect the findings to symptoms, protocols, and next-step testing instead of leaving them as a static report.
Commonly relevant for: Anxiety Depression, Brain Health Neurodegeneration, Heart Disease Prevention.
Gabriel difference
Why this becomes more useful inside Gabriel
Methylation dysfunction is at the root of countless chronic health issues: depression (can't make serotonin), fatigue (mitochondrial dysfunction), high homocysteine (cardiovascular risk), poor detoxification (can't clear estrogen or toxins), and accelerated aging (impaired DNA repair). Gabriel uses methylation panel data to identify bottlenecks in your methylation cycle and to design targeted protocols with methylated B vitamins (methylfolate, methylcobalamin), methylation cofactors (magnesium, zinc, choline), and methylation support nutrients (TMG, betaine) — personalized to your biochemistry.
Gabriel interprets results through a functional, root-cause lens: optimal ranges, pattern recognition across multiple diagnostics, and what the findings actually mean for action rather than just classification.
That means this test can feed directly into protocols, practitioner matching, food strategy, and follow-up testing instead of ending as a one-off PDF or lab portal result.
What to expect
What to expect from ordering to results
01
Order
Order directly through Doctor's Data or ask Gabriel whether there is a better path first.
02
Complete
A fasting blood draw at a local lab or specialty lab. Fast for 10–12 hours (water only).
03
Interpret
Upload the results to Gabriel for pattern recognition, protocol suggestions, and next-step guidance.
Frequently asked questions
Questions people usually ask before ordering
Methylation is a biochemical process that happens billions of times per second in your body. It's critical for DNA repair, detoxification, neurotransmitter production, immune function, and energy metabolism. Impaired methylation is linked to cardiovascular disease, depression, cancer risk, and chronic fatigue.
It typically measures homocysteine, methylmalonic acid (B12 status), folate, B12, SAMe/SAH ratio, and sometimes MTHFR genetic variants. Together, these reveal whether your methylation cycle is running efficiently or has bottlenecks that need targeted support.
MTHFR is a gene that helps convert folate into its active form (methylfolate). About 40% of the population has at least one variant. Having a variant doesn't guarantee problems, but it means you may need methylfolate instead of folic acid and should monitor homocysteine levels. Two copies of C677T is more clinically significant.
Blood methylation markers (homocysteine, B12, folate, methylmalonic acid) cost $75-150 through direct labs. MTHFR genetic testing adds $100-200. Insurance covers homocysteine and B12 with appropriate diagnosis codes.
Not sure which test belongs in your workup?
Tell Gabriel your symptoms, goals, and what you have already tried. You will get a more useful answer than a generic test catalog can give you.